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Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-Degrader

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllBeOne Medicines
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In plain words

What the trial is, and whether it could suit you

This study aims to explore the recommended phase 2 dose and evaluate the safety, tolerability and preliminary antitumor activity of BGB-16673 monotherapy at the recommended Phase 2 dose for the selected B-cell malignancy expansion cohorts

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Key Inclusion Criteria 1. Provision of signed and dated written informed consent prior to any study-specific procedures, sampling, or data collection 2. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2 3. Adequate hematologic, coagulation, renal, pancreatic, and hepatic function, and measurable disease according to disease-specific criteria, as applicable 4. Phase 1: Confirmed diagnosis of R/R Marginal Zone Lymphoma (MZL), Follicular Lymphoma (grade 1-3a), Waldenström Macroglobulinemia (WM), non-germinal center B-cell (non-GCB) diffuse large B-cell lymphoma (DLBCL), Richter's transformation to DLBCL, MCL, or CLL/SLL 5. Phase 2: Confirmed diagnosis of MCL, or CLL/SLL 6. Highly effective method of birth control during study treatment period, and for ≥ 30 days after the last dose of the study drug Key Exclusion Criteria 1. Prior malignancy (other than the disease under study) within the past 2 years, except for curatively treated basal or squamous skin cancer, superficial bladder cancer, carcinoma in situ of the cervix or breast, or localized Gleason score ≤ 6 prostate cancer 2. Require ongoing systemic treatment for any other malignancy or systemic corticosteroid treatment 3. Current or history of central nervous involvement 4. Prior autologous stem cell transplant unless ≥ 3 months after transplant, prior chimeric cell therapy unless ≥ 6 months after cell infusion, prior allogeneic stem cell transplant ≤ 6 months before the first dose of the study drug Note: Other protocol defined Inclusion/Exclusion criteria may apply
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What it tests

  • Tacabrutideg
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Where

29 sites
The First Affiliated Hospital of Bengbu Medical University
Bengbu, China
Anhui Provincial Hospital
Hefei, China
Peking University Third Hospital
Beijing, China
Beijing Chao Yang Hospital,Capital Medical University
Beijing, China
Second Affiliated Hospital of Army Medical University (Xinqiao Hospital)
Chongqing, China
Fujian Medical University Union Hospital
Fuzhou, China
Sun Yat Sen University Cancer Center
Guangzhou, China
Guangdong Provincial Peoples Hospital Huifu Branch
Guangzhou, China

…and 21 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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