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โ† Trials
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Effects of Neuronavigated Theta Burst Stimulation in Therapy of Post-stroke Aphasia

RecruitingNAAges 18 Years - 75 YearsAllInstitute of Psychiatry and Neurology, Warsaw
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In plain words

What the trial is, and whether it could suit you

Aphasia is an impairment in the ability to express and/or understand language, commonly observed after stroke to the language dominant (left) hemisphere. Despite natural tendency to spontaneous functional recovery in the first months post stroke and language improvement due to application of behavioral speech and language therapy (SLT), many aphasic patients do not achieve satisfactory level of verbal communication. The aim of the planned study is to explore the potential of the noninvasive repetitive Transcranial Magnetic Stimulation (rTMS) as a therapeutic tool for aphasia in addition to traditional behavioral therapy. In case of aphasia, studies on therapeutic effectiveness of rTMS aim to increase the activity of the language-dominant left cerebral hemisphere, which may be achieved in an indirect manner by inhibiting the activity of the opposite (right) hemisphere or in a direct manne

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * First-ever left middle cerebral artery ischemic stroke (brain damage localization confirmed by magnetic resonance imaging, MRI) * 3 or more months from the onset of stroke * Non-fluent aphasia (confirmed in the BDAE test) with functional communication difficulties ranging from mild to significant (grades from 2 to 4 in ASRS), marked difficulties in naming, and relatively preserved everyday speech comprehension * Native Polish speaker * Right-handedness prior to stroke * Signing of the informed consent for the participation in the study. Exclusion Criteria: * Psychiatric and/or neurological comorbidity (e. g. dementia, depressive disorder, alcohol dependence) * Diagnose of epilepsy or epileptic changes in EEG, also frequent losses of consciousness of unclear etiology which might suggest epileptic seizures * History of any neurosurgical procedure around the head area * 1.5 T MRI examination contraindications (metal elements in the body, e. g. implantable cardioverter-defibrillator, deep brain stimulation devices; claustrophobia) * Regular intake of medication that could affect cortical excitability (e. g. antiepileptic or antipsychotic drugs, antidepressants, benzodiazepines) or medication influencing neuroplastic processes (e. g. dopamine) * Significant cognitive impairment limiting patient's cooperation during assessment and behavioral aphasia therapy * Visual deficits significantly hindering the perception of therapeutic tasks presented visually on a computer's screen * New neurological episode (e. g. another brain stroke) or somatic illness (e. g. COVID-19) during the cycle of the therapy, requiring its interruption.
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What it tests

  • Noninvasive transcranial brain stimulation: excitatory iTBS
  • Noninvasive transcranial brain stimulation: inhibitory cTBS
  • Individual speech-language therapy (SLT)
  • Sham TBS simulating left hemispheric iTBS
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Where

1 site
Institute of Psychiatry and Neurology
Warsaw, Poland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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