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Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

RecruitingNAAges 18 Years - anyAllUniversity of Southern California
NCT05307055 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to determine whether direct brain stimulation of specific regions and ranges improves cognition in people with Parkinsons Disease (PD) who already have a deep brain stimulator implanted. Research activities consist of 32 subjects undergoing stimulation changes to their device and being administered neurocognitive tests to evaluate the changes. An fMRI scan will also be done at baseline and at weeks 15 and 27. All subjects will undergo the stimulation changes in a randomized double blind crossover study. Evaluation of stimulation changes will be assessed through analysis of neurocognitive data.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Male or female patients who had previously undergone bilateral STN deep brain stimulation implantation 2. Age \>18 years old 3. Stable medication regimen for at least 3 months. 4. Patient informed and able to give written consent 5. Able to comply with all testing, follow-ups and study appointments and protocols Exclusion Criteria: 1. History of epilepsy or seizure 2. History of dementia 3. History of major substance abuse
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What it tests

  • STN DBS - Theta Burst
  • STN DBS - Gamma
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Where

1 site
University of Southern California Keck School of Medicine
Los Angeles, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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