🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Development of a Battery of Audiological Tests for the Precision Diagnosis of Age-related Hearing Loss

RecruitingNAAges 18 Years - anyAllInstitut Pasteur
NCT05312983 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Age-related hearing loss, or presbycusis, is caused by many genetic and environmental factors. Its prevalence poses a public health challenge of early identification and effective hearing aid treatment. However, the lack of screening and of a validated audiological test battery to diagnose an individual's needs and to guide hearing aid adjustments is a major obstacle. Furthermore, monogenic forms of hearing loss affect only one functional module of hearing. The audiological test(s) dependent on the function of this module are affected, in a progressive manner, but not the others. A previous study showed that in early onset presbycusis patients, a quarter of the subjects tested were affected by monogenic presbycusis. The collection of audiological and vestibular tests, carried out on proven monogenic presbycusis patients and compared to that of normal hearing patients, would constitute

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: For all participants: * Be over the age of 18, * Be affiliated to a social security system, * Have a good command of the French language (oral and written). For the group of participants with anticipated presbycusis: * Over the age of 40, having a hearing aid recipient or coming for a first hearing aid recipient * Between 18 and 40, having a hearing aid recipient, coming for a first hearing aid recipient or declare a progressive genetic birth defect For healthy volunteers: \- Have no known hearing loss. Exclusion Criteria: * Report having been chronically exposed to loud sounds. * Have a history of ototoxic substances, * To have sequelae of ear infections and/or a history of ENT disease that permanently affects hearing or balance, * Have an ethnic origin for which the Pasteur Institute does not have information on the frequency of variants of the genes studied. * Have type II diabetes, * Have a neurological or psychiatric condition that interferes with comprehension or ability to move, * Be under guardianship, * Be deprived of liberty by judicial or administrative decision, or be subject to legal protection, * Not being subject to a social security system, * Taking narcotic substances, alcohol or medication that diminishes cognitive abilities.
💊

What it tests

  • Audiological and vestibular tests
  • Blood sampling
  • neurocognitive self-questionnaire
📍

Where

2 sites
Laboratoire de correction auditive
Paris, France
CEntre de Recherche et d'Innovation en Audiologie Humaine
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy