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Moderate Hypofractionated Boost to the Prostate With Pelvic RT in High Risk Prostate Cancer

RecruitingNAAges 18 Years - anyMaleUniversity Health Network, Toronto
NCT05313815 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a single-arm phase II prospective trials that is recruiting 100 participants. The study population that is being investigated are patients with localized high-risk or node-positive prostate cancer. Participants will receive external beam radiotherapy as a moderately hypofractionated boost to the prostate with pelvic radiation therapy. Androgen deprivation therapy will be prescribed at the discretion of the treating physician as per standard of care.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years. * Able to provide informed consent. * Histologic diagnosis of prostate adenocarcinoma. * ECOG performance status 0-1. * High-risk localized disease by NCCN criteria (\>cT3, Grade group \>4, or PSA \>20 ng/mL) or clinical N1 disease. * Clinical M0 by conventional imaging (computed tomography (CT) and bone scan (BS)) and/or molecular imaging (prostate specific membrane antigen (PSMA)- positron emission tomography (PET)) Exclusion Criteria: * Prior pelvic radiotherapy. * Contraindications to radiotherapy
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What it tests

  • Moderate hypofractionated boost to the prostate with pelvic RT (external beam radiotherapy)
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Where

1 site
Princess Margaret Cancer Center
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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