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Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer

RecruitingNAAges 18 Years - anyAllLondon Health Sciences Centre Research Institute …
NCT05314400 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

After a patient is diagnosed with colon cancer, they receive a CT of the chest, abdomen, and pelvis to see if the cancer has spread (metastasized) to other parts of the body. A common site for the cancer to spread to is the liver. If an abnormality is seen in the liver on CT, sometimes an MRI of the liver is required to determine a) whether it is cancer or not and b) whether there are small tumours in the liver that were not visible on CT. During the MRI, the patient is injected with intravenous (IV) contrast. This makes liver lesions more conspicuous and also helps determine if they are cancerous or not. The most commonly used IV contrast agent is called Gadovist. However, there is another IV contrast agent called Primovist that is better at detecting liver metastases from colon cancer than Gadovist. This is very important information for surgeons, because if they considering cutting o

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male or female, 18 years of age or older * Diagnosis of colorectal cancer, biopsy proven * Prior imaging showing liver lesions that may be metastases * Provision of signed and dated informed consent form * Willingness to comply with study procedures and availability for the duration of the study * Able to tolerate MRI required by protocol Exclusion Criteria: * Presence of implanted medical device or metallic object that is MR incompatible * Baseline eGFR of \< 30 mL/min/1.73 m2 * Severe claustrophobia not relieved by oral anxiolytics * Documented severe allergic-like reaction gadolinium-based contrast agent * Weight greater than allowable on MRI table * Pregnancy * Diffuse liver metastases, i.e. definitively unresectable * Severe liver dysfunction, ALBI grade 3
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What it tests

  • Full Gadoxetate-enhanced liver MRI
  • Shortened Gadoxetate-enhanced liver MRI
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Where

2 sites
St. Joseph's Healthcare
London, Canada
London Health Sciences Centre
London, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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