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โ† Trials
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Cough Audio Classification as a TB Triage Test

Recruitingn/aAges 12 Years - anyAllUniversity of Stellenbosch
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In plain words

What the trial is, and whether it could suit you

TB is the single biggest infectious cause of death (1.5 million died in 2018), killing more HIV-positive people than any other disease, and is arguably the most important poverty-related disease in the world. TB's estimated incidence in Africa has been declining over recent years but progress is slow and plateauing. To avert stagnation, truly innovative and ambitious technologies are needed, especially those that improve case finding and time-to-diagnosis as, in mathematical models based on the TB care cascade framework, interventions that accomplish this will have the most impact on disrupting population-level transmission, including when deployed at facilities where patients are readily accessible. Critically, these interventions (triage tests) must promote access to confirmatory testing (e.g., Xpert MTB/RIF Ultra) by enabling patients to be referred rapidly and efficiently during the

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * participant must be at least 12 years old * participant must have a prolonged cough (for at least two weeks) * participant must provide informed consent * participant shall have a known HIV status or be willing to undergo standard of care HIV testing and counseling Exclusion Criteria: * individuals who refuse informed consent * individuals who have received treatment for TB in the 60 days prior to enrolment * individuals who are unable to provide a sputum specimen for microbiological testing * individuals who have haemoptysis or a bloody cough with any forced coughs for audio recordings
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What it tests

  • Cough sounds
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Where

2 sites
Stellenbosch University
Cape Town, South Africa
Makerere University
Kampala, Uganda
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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