🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Predictive Outcome in Comatose Patients

Recruitingn/aAges 18 Years - anyAllAssistance Publique - Hôpitaux de Paris
NCT05321459 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Evaluating the prognosis of comatose patients after cardiac arrest (CA) in the intensive care unit (ICU) remains challenging. It requires a multimodal approach combining standardized clinical examination, serum biomarkers, imaging and classically electrophysiological examinations, (among them auditive evoked potentials or AEP) but none has a sufficient sensitivity/specificity. In a preliminary study, the investigators developed an algorithm from the signal collected with AEP, and generated a probability map to visually classify the participants after the algorithm processing. Participants could be classified either with a good neurological prognosis or with bad neurological prognosis or death. The investigators hypothesize that the "PRECOM" tool, applied blindly to a large prospective multicenter cohort of patients admitted to intensive care for coma in the aftermath of CA will predict

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Age above18 years old * Patient affiliated to a French Heath Care Insurance * Admitted in the intensive care unit (ICU) for coma post extra- or intra-hospital cardiac arrest (CA) with shockable or non-shockable rhythm * Persistent coma on day 3 after post CA, defined by the inability to respond to a verbal command in an appropriate manner (motor Glasgow components ≤ 3) and at the time of neurophysiological recordings (D3-D7 ± week -end). Exclusion Criteria: * Decision to limit resuscitation therapies taken by the resuscitation team * Inability to perform the auditory evoked potentials (AEP) (deafness, skin lesion or any condition preventing to record AEP). * Opposition by the trusted person or by the patient once he/she wakes up
💊

What it tests

  • Neurological prognosis
📍

Where

7 sites
APHP Avicenne Hospital - Réanimation médico-chirurgicale
Bobigny, France
APHP Lariboisière Hospital, Clinical Physiology Department
Paris, France
APHP Laribosière Hospital - Service de Réanimation Médical et Toxicologique
Paris, France
APHP Cochin Hospital - médecine intensive-réanimation
Paris, France
APHP HEGP hospital - Réanimation médicale
Paris, France
APHP Bichat Hospital -Médecine intensive - réanimation infectieuse
Paris, France
Delafontaine Hospital - médecine intensive-réanimation
Saint-Denis, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy