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Renal Biopsies in Post-liver Transplantation Patients With Renal Impairment

Recruitingn/aAges 18 Years - 75 YearsAllRenJi Hospital
NCT05326399 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Investigators will conduct this single-center, prospective cohort study to explore the prevalence and risk factors of renal function progression in post-liver transplantation patients with renal impairment after renal biospy and to understand the the pathology of kidney disease in post-liver transplantation patients with renal impairment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * age 18-75 years * patients received liver transplantation * new onset of proteinuria(defined as 24-hour proteinuria\>1g/24h, or Urinary albumin creatinine ratio(UACR)\>300mg/g on at least two occasions), and/or renal impairment: eGFR \<60 mL/min/1.73 m² at least two occasions, and/or serum creatinine increase ≥50% from baseline * have received renal biopsy in the past 3 months * Signed informed consent form(ICF) Exclusion Criteria: * patients received renal transplantation * hepatic failure * severe bleeding risk or platelet \<70\*109/L * chronic kidney insufficiency with eGFR\<30ml/min·1.73m2,or kidney atrophy, or solitary kidney, or medullary sponge kidney, or polycystic kidney, or obstructive nephropathy * uncontrolled mental disease or unable to cooperate during operation * Pregnancy or lactation * not suitable for this study judged by investigaters
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What it tests

  • renal biospy
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Where

2 sites
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China
Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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