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Sex Differences in Metabolism Following a High-fat Meal

RecruitingNAAges 18 Years - 35 YearsAllKirsten Bell
NCT05332301 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (\>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2 diabetes. Women tend to be better protected against the development of high-fat diet-induced insulin resistance compared with men, but it is not fully understand why this sex difference exists. It is possible that women metabolize high-fat meals differently than men, which might explain why they are less likely to develop type 2 diabetes over the course of their lifetime. However, no one has ever compared the metabolic response to a high-fat meal between men and women in the hours immediately after ingestion. During this study, the investigators will administer a single high-fat "fast-food" style breakfast meal (846 kcal, of which 58% is fat) to 24 health young adul

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📋 Eligibility rules (as published)
Inclusion Criteria: * BMI between 18.5 and 30.0 kg/m2 * Weight stable for the past 6 months (± 2kg) * Exercise at or below the Canadian Physical Activity Guidelinesa * Fasting blood glucose \<6.0 mM * Resting blood pressure \<140/90 mmHg * No hormone-altering contraceptive use (e.g., pill, patch, ring, injection) Exclusion Criteria: * Smoking * Diabetes, cancer, or other metabolic disorders * Cardiac or gastrointestinal problems * Infectious disease * Barium swallow or nuclear medicine scan in the previous 3 weeks * Pregnant or breastfeeding * Diagnosis of polycystic ovary syndrome * Follow a vegan or vegetarian diet * Not fully vaccinated against COVID19
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What it tests

  • High-fat test meal
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Where

1 site
McMaster University
Hamilton, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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