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The Effect of Beta-blocker on Chronotropic Response and Cardiorespiratory Fitness in Patients With Atrial Fibrillation

RecruitingNAAges 20 Years - anyAllNational Taiwan University Hospital
NCT05332457 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a prospective study to evaluate changes in exercise capacity and chronotropic response to exercise before and after beta-blocker dosage reduction in patients with atrial fibrillation (AF).

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. \> 20 years of age. 2. Clinically stable patients with persistent atrial fibrillation using beta-blocker as rate-control agent without dosage adjustment for at least 3 months. 3. Resting heart rate \< 80 bpm. 4. Left ventricular ejection fraction \> 50%. Exclusion Criteria: 1. Beta-blocker usage due to indications other than rate control for atrial fibrillation. 2. Inability to perform a cardiopulmonary exercise testing. 3. Presence of contraindications for cardiopulmonary exercise testing according to the American College of Sports Medicine's Guidelines for Exercise Testing and Prescription. 4. Patients with implantable cardioverter defibrillator or pacemaker. 5. Pregnancy. 6. Inability to provide informed consent.
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What it tests

  • Reduced dosage of beta-blocker
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Where

1 site
National Taiwan University Hospital
Taipei, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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