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Lopinavir/Ritonavir in PLWH With High-Grade AIN

RecruitingPhase 1Ages 18 Years - anyAllUniversity of Wisconsin, Madison
NCT05334004 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is being done to assess the safety of lopinavir/ritonavir in patients with PLWH with AIN. 30 participants will be recruited and can expect to be on active study for approximately 3 months and long term follow up for 40 weeks.

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📋 Eligibility rules (as published)
Inclusion Criteria: * willing to provide informed consent * greater than or equal to 18 years of age * Diagnosis of biopsy-confirmed HGAIN * willing to comply with all study procedures Exclusion Criteria: * Diagnosis of low-grade anal dysplasia (AIN, low-grade squamous intraepithelial lesion (LSIL)) by HRA. * CD4 count less than 200 cells/mm\^3 at the time of consideration for entry into the study * unable to provide informed consent * Pregnant or breastfeeding female * Currently receiving systemic chemotherapy or radiation therapy for another cancer.
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What it tests

  • Lopinavir / Ritonavir
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Where

1 site
UW Digestive Health Center Anoscopy Clinic
Madison, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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