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Determination of Pancreatic Steatosis Prevalence and Correlation With High-risk Cyst Features

RecruitingNAAges 18 Years - anyAllChinese University of Hong Kong
NCT05334836 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pancreatic cancer is the fifth leading cause of cancer mortality in Hong Kong and the seventh leading cause of cancer mortality worldwide. In 2020, approximately 496000 new cases of pancreatic cancers were diagnosed globally . Pancreatic cancer is a highly fatal cancer with a case-fatality rate of 94.0% globally. In Hong Kong, both the incidence and mortality of pancreatic cancer have increased over the past decade. Due to the deep-seated location of pancreas, it is difficult to diagnose pancreatic cancer at an early stage, which in turn leads to delays in cancer treatment and poorer survival. Despite advances in oncologic treatment, the 5-year survival rate of metastatic pancreatic cancer remains poor (\~2.9%). As such, there has been growing interest to improve pancreatic cancer prevention and survival by: 1. reduction of modifiable risk factors (eg, cigarette smoking, obesity, diabe

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age 18 or older 2. Patients with at least 1 pancreatic cystic lesion presumed to be IPMN or MCN based on CT, MRI or EUS features, with a cyst size ≥ 5mm; or healthy subjects. 3. Patients who are able to provide written informed consent to participate in the study and comply with the study procedures. Exclusion Criteria: 1. Unable to provide written informed consent 2. Patients with metallic implants or other contraindications to MRI 3. Patients with contraindications for endoscopy due to comorbidities 4. Patients with known pancreatic cancer or prior pancreatic resection 5. Patients with significant alcohol consumption, defined as alcohol intake of over 20 g daily (140 g weekly) for men and 10 g daily (70 g weekly) for women
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What it tests

  • MRI for pancreatic fat and liver fat quantitation
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Where

1 site
Prince of Wales Hospital, The Chinese University of Hong Kong
Shatin, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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