🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Non-invasive Goal-directed thErapy oN cIrcUlatory Shock

RecruitingNAAges 18 Years - anyAllUniversity of Sao Paulo
NCT05336357 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Circulatory shock occurs when the oxygen supply to the tissues decreases, leading to cellular damage and affecting about one-third of patients admitted to Intensive Care Units (ICUs). Cardiac Output (CO) is defined as the volume of blood ejected by the left ventricle per minute and is a crucial hemodynamic parameter for monitoring patients with signs of circulatory shock. However, this parameter is underutilized in patients treated in Emergency Units because its measurement typically involves invasive methods, which are not commonly available in this setting. Any method capable of measuring CO without the need for pulmonary artery catheter insertion is referred to as minimally invasive CO monitoring. Evaluating these parameters allows for a quicker determination of the etiology of circulatory shock, enabling the early initiation of goal-directed therapy. Goal-directed therapy has been pr

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria * Age \> 18 years; * Patients admitted to Emergency Units, Intensive Care Units, and Wards within 3 hours of the diagnosis of Septic Shock: * Systolic Blood Pressure (SBP) \< 90 mmHg and/or Mean Arterial Pressure (MAP) \< 65 mmHg (with or without norepinephrine at a dose less than 0.5 mcg/kg/min) + Clinical signs of infection and at least one of the following: * Lactate \> 2 mEq/L; * Oliguria (urine output \< 0.5 mL/kg/h for at least 6 hours); * Neurological changes (mental confusion, decreased level of consciousness, psychomotor agitation, temporal-spatial disorientation); * Capillary refill time \> 3 s (after digital compression for 10 seconds); * Poor skin perfusion. * Signed Informed Consent Form. Exclusion Criteria * Hospital admission time greater than 24 hours * Significant edema in the fingers * Severe peripheral vasoconstriction * Use of Norepinephrine at a dose greater than or equal to 0.5 mcg/kg/min * Presence of significant Aortic Insufficiency * Patients undergoing Renal Replacement Therapy * Patients with ST-segment elevation Myocardial Infarction * Patients requiring Invasive Mechanical Ventilation * Patients already participating in another study
💊

What it tests

  • Goal-Directed Therapy
📍

Where

1 site
Instituto do Coração
São Paulo, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy