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The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI

Recruitingn/aAges any - anyFemaleUniversitair Ziekenhuis Brussel
NCT05337072 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems. Today, diagnosis of chronic endometritis is not evident, since no well-validated classification scales are available. In the UZ Brussel the pathology department applies its own in-house scoring system, based on the presence and position of plasma cells within the histological images. Despite limited research so far, it recently became clear that the endometrium is colonized by micro-organisms (the microbiome). However, it is still unclear what role these microorganisms play in chronic endometritis and fertility problems. Chronic endometritis is often diagnosed in the context of fertility problems, and the patient is treated 'blindly' with broad-spectrum antibiotics such as dox

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women planned for IVF/ICSI treatment at Brussels IVF (UZ Brussel) * Women who undergo a diagnostic hysteroscopy in preparation of their treatment Exclusion criteria: * If an interventional instead of a diagnostic hysteroscopy in planned * In the occurence If a previous history of chronic endometritis and the use of antibiotics in the last 3 months.
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What it tests

  • Microbiome study
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Where

1 site
Universitair Ziekenhuis Brussel
Brussels, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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