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Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resistant Epileptic Patients

RecruitingNAAges 18 Years - anyAllCentral Hospital, Nancy, France
NCT05339438 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Anterior temporal epilepsy is the most frequent form of focal epilepsy (more than 50% of focal epilepsies). The epilepsy is drug-resistant when epileptic seizures persist despite antiepileptic treatment (25% of cases). In this case, it is possible to offer a surgical solution to the patient: an anterior temporal lobectomy. This surgery consists of removing the entire portion of the temporal lobe responsible for epilepsy (epileptogenic zone), that is to say a major part of the temporal pole, the hippocampus and the ventral anterior temporal lobe (vATL). The goal of the surgery is to lead to a disappearance of the seizures while preserving the functions of the patient. This is why a pre-surgical assessment is systematically carried out in order to locate the epileptic focus and to predict the risks of neurological and cognitive deficits. The vATL is of particular interest because it is a h

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult person, * Person affiliated to a social security scheme or beneficiary of such a scheme, * Person having received complete information on the organization of the Clinical Investigation and having signed informed consent, * Person having carried out a preliminary clinical examination adapted to the Clinical Investigation, * For patients: Person with drug-resistant structural focal epilepsy of the anterior temporal lobe (right or left), candidate for epilepsy surgery (anterior temporal lobectomy), * For healthy volunteers: Person with no known pathology in the anterior temporal lobe (particularly epilepsy). Exclusion Criteria: * Contraindication to MRI including claustrophobia, * Uncorrected visual disturbances, * Person unable to give consent, * Lack of mastery of the French language or ability to understand instructions, * Person referred to in Articles 64, 65 and 66 of European Regulation 2017/745: Person of full age unable to consent alone to participate in the Clinical Investigation; Minor; Pregnant or breastfeeding woman.
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What it tests

  • functional MRI
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Where

1 site
Centre Hospitalier Régional Universitaire de Nancy
Nancy, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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