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Optimizing Graft Selection for ACL Reconstruction

RecruitingNAAges 18 Years - 40 YearsAllHvidovre University Hospital
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In plain words

What the trial is, and whether it could suit you

Purpose: To investigate the differences between the three most common methods for reconstruction of the anterior cruciate ligament (ACL), to support the development of the best method for the individual patient. Main research area: ¨ Sports Orthopedic Surgical research. State of the art: Every year in Denmark 2500 patients receive surgical reconstruction surgery to replace a ruptured ACL. Many patients experience a decline in knee function and 4-12% suffer a new ACL rupture within 5 years. According to data from the Danish ACL register, three methods of reconstruction are most prevalent, but with large variation between hospitals. This indicates lack of consensus on optimal surgical procedure. Design: Assessor-blinded randomized controlled study. 150 patients aged 18-40 with ruptured ACL are allocated to reconstruction with tendon(s) harvested from either the semitendinosus and gra

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📋 Eligibility rules (as published)
List of Inclusion criteria * clinically confirmed first-time ACL rupture * Current injury sustai´ned within 2 years * high activity level prior to ACL rupture (Tegner score ≥ 3) and personal goal of returning to physical activity. List of preoperative exclusion criteria * Inadequate Danish language skills to answer questionnaires. * Prior ligament surgery in the injured knee * Prior ligament surgery in the non-injured knee * Instability of the non-injured knee * Known osteoarthritis (Kelgren Lawrence score ≥ 2) * Prior open surgery to either knee * Prior severe fracture involving knee joint surfaces * Prior severe injury to thigh muscles in either leg (e.g. tear or compartment) * Prior severe injury to the patella tendon of either knee (e.g. subluxation) * Medical condition preventing full participation (e.g. active cancer, - rheumatoid arthritis) * Psychiatric condition preventing full participation * Pregnancy * Obesity (BMI \> 30) List of Perioperative exclusion criteria (Arthroscopy) * Medial meniscus lesion \> 50% * Lateral meniscus lesion \> 50% * Treated Meniscal root lesion or radial meniscal tear that require restrictive regimen * Cartilage lesion \>2cm2, Articular cartilage injury classification (ICRS) grade 3 * Concurrent ligament injury (except medial collateral ligament (MCL) lesion grade 1-2)
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What it tests

  • QT graft
  • ST/Gr graft
  • BPTB graft
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Where

1 site
Copenhagen University Hospital - Amger/Hvidovre
Hvidovre, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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