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Quality of Life and Economic Repercussions of Combining Proactive Medication Assessment and Electronic Monitoring of Toxicities in Subjects Undergoing Oral Cancer Therapy

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Universitaire de Nīmes
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In plain words

What the trial is, and whether it could suit you

Therapies used to treat cancer are administered orally (OT) in 75% of cases, lending themselves to outpatient care. This care pathway raises new issues: specific toxicities, drug interactions, and the relationship between the community (physicians and pharmacists) and the hospital. Drug interactions can increase toxicities or decrease the effectiveness of treatment and impact overall survival. Detection of drug interactions before treatment initiation is not always performed in routine practice. However, these oral treatments have a low therapeutic index and are associated with side effects that can alter quality of life (QoL). They are classically documented by the physician at the time of the consultation using the Common Terminology Criteria for Adverse Events (CTCAE), which makes it possible to adapt management. Nevertheless, numerous studies have shown a discrepancy between side ef

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient starting oral therapy treatment in oncology for metastatic or locally advanced cancer * Patient able to use a connected electronic object * Patient with a smartphone/tablet or computer with internet access and an email address. * Patient with WHO status ≤2 * Patients receiving other cancer therapy concurrently with oral therapy may be included * The patient must have given their free and informed consent and signed the consent form * The patient must be a member or beneficiary of a health insurance plan Exclusion Criteria: * The subject is participating in a category 1 interventional study, or is in a period of exclusion determined by a previous study * The subject refuses to sign the consent * It is impossible to give the subject informed information * The patient is under safeguard of justice or state guardianship * Patient pregnant, parturient or breast feeding * Illiterate patient * Patients with poor prognosis due to a serious uncontrolled medical condition, mild systemic disease, uncontrolled infection (cardiac, pulmonary, renal, etc.) * Patient receiving hormone therapy alone for breast or prostate cancer
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What it tests

  • THESS monitoring
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Where

6 sites
Centre Hospitalier Dubois Brive
Brive-la-Gaillarde, France
Chic Castres-Mazamet
Castres, France
Centre Hospitalier Emile ROUX
Le Puy-en-Velay, France
CHU de Nîmes
Nîmes, France
Institut cancerologie du Gard
Nîmes, France
Médipôle Lyon-Villeurbanne
Villeurbanne, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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