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Breaking up Prolonged Sedentary Behavior to Improve Cardiometabolic Health

RecruitingNAAges 18 Years - anyAllColumbia University
NCT05353322 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this Phase 1 research study is to answer two questions: (1) How frequent should periods of prolonged sedentary time be interrupted? and (2) What is the appropriate duration or length of time of these breaks in sedentary time? To address these questions, this project will conduct a state-of-the-art adaptive dose finding study under controlled laboratory conditions to determine the minimally effective dose (the smallest dose) that yields cardiometabolic benefit for two separate sedentary break elements (frequency and duration). Study findings will ultimately determine how often and for how long people should break up periods of prolonged sedentary time to transiently improve established cardiovascular risk factors; key foundational information critical to the success of future long-term trials and ultimately public health guidelines. Primary Aim: To determine the minimally

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age or older * Ability to read, write and speak English or Spanish * Limited or no chronic medical conditions \[examples include but not limited to: CVD, diabetes, chronic obstructive pulmonary disease (COPD), HIV/AIDS; participants with high blood pressure/hypertension and/or high cholesterol/hyperlipidemia may be included if they are currently prescribed and taking medication for these conditions\] * Do not take medication (over-the-counter or herbal) to control glucose (such as a diabetes control medication) * Not currently pregnant * Do not currently smoke cigarettes * No pre-existing musculoskeletal conditions (including but not limited to osteoarthritis, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis) that would prevent participation in intermittent physical activity * No allergies to common food allergens including wheat, eggs, milk or other dairy, gluten, fructose, peanuts or other nuts * No dietary restrictions such as vegan, gluten free, halal Exclusion Criteria: • Unable to provide consent
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What it tests

  • Sedentary Break (Walking) Condition
  • Sitting (Control) Condition
  • Controlled Diet
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Where

1 site
Center for Behavioral Cardiovascular Health
New York, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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