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GI Oxalate Absorption

RecruitingNAAges 18 Years - 70 YearsAllUniversity of Chicago
NCT05356000 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to learn more about how oxalate, a compound found in many foods, may affect a person's chances of forming kidney stones. Active participation in this study will last for around one week. For the first two days, subjects will be asked to eat a special diet at home. From Days 3-5, they will eat special meals delivered to their home from a research clinic at the University of Chicago. They will also collect 24-hour urine samples at home on Days 4 and 5. On Day 6, they will come in to the research clinic at the University of Chicago in Hyde Park, where they will spend most of the day. They will receive a special liquid that contains oxalate, and we will have them eat a specially prepared breakfast that is low in oxalate and citrate.

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📋 Eligibility rules (as published)
Inclusion Criteria: Post-Roux-en-Y gastric bypass stone formers: * Age 18-70 * Previous history of Roux-en-Y gastric bypass * History of at least one calcium-based kidney stone after surgery * Pre-protocol urine oxalate above the lab normal range (50mg/day) Obese stone formers: * Age 18-70 * Body mass index (BMI) \>=30kg/m2 * History of at least one calcium-based kidney stone * Pre-protocol urine oxalate above the lab normal range (50mg/day) Non-obese stone formers: * Age 18-70, BMI between 18.5-29.9 kg/m2 * History of at least one calcium-based kidney stone Exclusion Criteria: Post-Roux-en-Y gastric bypass stone formers: * History of colon resection (partial or complete) * History of duodenal switch bowel surgery * History of ileal-jejunal bypass surgery * History of primarily uric acid, cysteine, or struvite stones Obese and non-obese stone formers: * History of bowel surgery * History of colon resection * History of inflammatory bowel disease (Crohn's disease, Ulcerative Colitis) * History of primarily uric acid, cysteine, or struvite stones
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What it tests

  • Special low-oxalate diet followed by all-day visit to University of Chicago research clinic
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Where

1 site
University of Chicago Medical Center
Chicago, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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