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FGF23 and Cardiovascular Damage in Anemia With an Without Chronic Kidney Disease.

Recruitingn/aAges 18 Years - 85 YearsAllMaimónides Biomedical Research Institute of Córdo…
NCT05356325 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Anemia is associated with cardiovascular disease. Iron deficiency is usually induced in chronic kidney disease (CKD). In clinical studies, an inverse association between serum levels of iron and fibroblast growth factor 23 (FGF23), a cardiovascular risk factor, has been demonstrated. In addition, a number of the I.V. iron presentations mostly used to treat anemia show unwanted side effects related to phosphate alterations and increased FGF23. Objectives. The General Objective of this project is to evaluate, through in vivo and in vitro studies, the cardiovascular alterations related to the anemia-induced increase in FGF23 production; as well as the identification of possible molecular targets that may be useful in its prevention and/or palliation. Specific Objectives are: 1) To determine in a population with anemia (due to iron deficiency), with and without CKD, an association between th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Hemoglobin \< 11g/dl * Serum ferritin \< 100 ng/ml or transferrin saturation index \< 20% Exclusion Criteria: * Weight \< 50 Kg or BMI \< 17 * Acute bleeding \> 500 ml, within 72 hours before study inclusion * Proliferative hematologic disease. Hemochromatosis * Active infections within 30 days before study inclusion * Systemic inflammatory illness * Human immunodeficiency virus (HIV), Hepatitis C virus (HCV) or Hepatitis B virus (HBV) infection * Iron active treatment * Blood transfusion in the last 90 days before inclusion. * Cardiovascular hospitalization 30 days before study inclusion * Anticoagulant treatment with coumarins * Chronic liver disease * Immunosuppressive therapy * Erythropoiesis stimulating agents treatment, radiotherapy or chemiotherapy within 30 days before inclusion * Scheduled major surgery during study period * Pregnancy or lactation * Drugs addiction * Participation in others clinical trials.
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What it tests

  • Not listed
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Where

1 site
Hospital Universitario Reina Sofia
Córdoba, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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