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Physiological Ventricular Pacing Vs Managed Ventricular Pacing for Persistent AF Prevention in Prolonged AV Interval

RecruitingNAAges 18 Years - anyAllQuovadis Associazione
NCT05367037 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A multicenter, prospective, randomized study in a 1:1 ratio, single-blind with double-blind evaluation to evaluate the superiority of physiological ventricular pacing (proposed modality) vs. managed ventricular pacing (control) for prevention of persistent AF (PeAF) occurrence in patients with prolonged atrioventricular interval (PR≥180 ms) and indication for pacing: sinus node disease and/or paroxysmal type 1 or 2-second degree AV block.

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📋 Eligibility rules (as published)
Inclusion Criteria: 18 years older patients, able to express Informed Consent, with prolonged atrioventricular interval (PR\>180 ms) and one of the following indications for PM implantation according to current guidelines: * Sinus node disease. * Paroxysmal type1or 2 second-degree AV-block. Exclusion Criteria: * Candidacy for implantable cardioverter-defibrillator or cardiac resynchronization therapy device implantation. * Severe grade mitral or aortic regurgitation/stenosis. * Atrial fibrillation ablation (left pulmonary veins). * Cardiac surgery \< 3 months before PM implantation. * History of long-standing persistent AF. * Permanent third-degree AV block. * Participation in another clinical trial in the past 3 months. * Pregnancy or intention to become pregnant. * Life expectancy of \< 3 years.
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What it tests

  • PhysioVP
  • DDD-VPA
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Where

1 site
Elettrofisiologia, Cardiologia, Ospedale di Rovigo
Rovigo, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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