Prediction of Hepatocellular Carcinoma Recurrence After Curative Treatment by Monitoring Circulating Tumor DNA

Inclusion Criteria: 1. Age ≥ 18 years 2. HCC diagnosed on consensus radiological criteria in cirrhotic patients (EASL-EORTC 2012): helical CT or MRI with triple arterial, portal and late acquisition. The diagnosis is based on the presence of hypervascularization at the early arterial time (wash-in) with wash-out (hypodensity or hypointensity compared to non-tumor liver parenchyma) at the portal phase or late phase compared to non-tumor parenchyma. 3. HCC diagnosed histologically in the absence of a diagnosis on imaging (see IC n°2 above) 4. Patient operated on for liver resection or radiofrequency destruction 5. Treatment decision validated by the digestive oncology PCR 6. Patient having read and understood the information letter and signed the non-opposition form 7. Patient follow-up at the Charles Nicolle University Hospital in Rouen Exclusion Criteria: 1. Other active cancer or hematological malignancy 2. Contra-indication to surgery 3. Patient not affiliated to the social security system 4. Pregnant woman or parturient or breastfeeding 5. Person under court protection, sub guardianship or curatorship