🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Neural Mechanisms of Response Inhibition Training for OCRD

RecruitingNAAges 18 Years - 60 YearsAllUniversity of Wisconsin, Milwaukee
NCT05377125 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and/or skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of comput

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * age between 18 and 60 * moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7) * a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD) * estimated IQ \> 80 * presence of a RI deficits (SSRT ≥ 215ms). Exclusion Criteria: * Current substance use disorder * Severe ADHD * Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia * Current psychotherapy * Change in psychotropic medication status within 8 weeks before the study or during the study * Use of stimulant medication * Active suicidal risk * Contraindications for MRI procedures
💊

What it tests

  • Computerized cognitive training
  • Computerized placebo training
📍

Where

1 site
UWM Anxiety Disorders Laboratory
Milwaukee, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy