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Personalized Perioperative Analgesia Platform (PPAP) for Cesarean Section

RecruitingNAAges 18 Years - anyFemaleSenthil Sadhasivam
NCT05380531 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this collaborative CTSA (Clinical and Translational Science Award) application is to develop an innovative perioperative precision analgesia platform (PPAP) to improve analgesia and reduce serious immediate and long-term adverse outcomes of perioperative opioids in breastfeeding mothers and their infants

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📋 Eligibility rules (as published)
Inclusion Criteria: Adult women (\>18 yr) All races American Society of Anesthesiologists Classification (ASA) physical status: 1 to 3 undergoing elective Cesarean section that are willing to receive in-patient opioids. Exclusion Criteria: 1. Health conditions including uncontrolled diabetes (gestational or pre-existing) or hypertension (pre-eclampsia, eclampsia, or chronic) 2. Any history of opioid misuse before or during pregnancy-per self-report and clinical notes 3. Preoperative severe pain and opioid use/misuse, allergy to oxycodone 4. Allergy to oxycodone 5. Significant neurological disorders, liver and renal diseases
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What it tests

  • Preoperative Genotyping
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Where

4 sites
Riley Children's Hospital- Clinics / Labor and Delivery Unit
Indianapolis, United States
Washington University Hospital
St Louis, United States
UPMC Magee Women's Hospital
Pittsburgh, United States
University of Pittsburgh
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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