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Biomarkers Predictive of Thymic Evolution and Therapeutic Response at 2 Years in Patients With a First Psychotic Episode

RecruitingNAAges 15 Years - 30 YearsAllUniversity Hospital, Brest
NCT05384392 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Psychosis is a severe, common, and disabling psychological disorder. An epidemiological study conducted in England reported an incidence of 34 new cases per 100,000 person-years, with a peak between 16 and 19 years of age. Following a first psychotic episode, two clinical evolutions are possible: thymic psychosis (17%) and non thymic psychosis (83%). The first includes bipolar disorders with a psychotic component and major depressive disorders with a psychotic component; the second, other psychotic disorders, mainly schizophrenia. One of the major difficulties encountered is the frequent impossibility of specifying the type of psychosis at the beginning of the psychotic episode. However, these disorders require different therapies, particularly medication. This leads to a delay in diagnosis with a high risk of relapse. The semiological study of these diseases being carried out within th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient with a first episode of psychosis, * Aged between 15 and 30 years, * Able to consent and having signed a consent form (parental consent for minors). Exclusion Criteria: * Introduction or increase of antipsychotic and/or antidepressant and/or thymoregulatory treatment in the last month, * Mother tongue other than French, * Psychotic episode due to an organic disorder, * Psychotic episode induced by the use or withdrawal of toxic substances with severe dependence , * Intellectual deficit, * Chronic inflammatory disease, * Immunomodulatory treatment, * Contraindication to MRI, * Pregnant or breastfeeding woman, * Patient under court protection, guardianship, curatorship or deprived of liberty.
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What it tests

  • Recorded interview
  • Clinical scales
  • Blood sample
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Where

5 sites
Dr Efflam BREGEON
Angers, France
Dr Florian STEPHAN
Brest, France
Dr Anne SAUVAGET
Nantes, France
Dr Dominique DRAPIER
Rennes, France
Dr Vincent CAMUS
Tours, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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