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Metagenomic Study in Parapneumonic Effusion

Recruitingn/aAges 18 Years - anyAllChinese University of Hong Kong
NCT05394220 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Objective: To identify known and unknown bacterial pathogens in patients with pleural infections using a combination of conventional culture and next-generation sequencing approaches. Hypothesis to be tested: The investigators hypothesize that next-generation sequencing will serve as a comprehensive approach to identify culturable and unculturable bacterial pathogens in patients with pleural infections compared to the conventional culture. Design and subjects: This is a prospective cohort study to be conducted in the medical department of a tertiary care hospital in Hong Kong involving patients with pleural infection. Patients will be recruited if a pleural infection is suspected, with pleural fluid sampled and a 6-month follow-up. The clinical management by the medical team will not be interfered. Study instruments: Pleural fluid will be collected for conventional culture, 16S amplic

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📋 Eligibility rules (as published)
Study group (patients with parapneumonic effusion) Inclusion Criteria: * Patients hospitalized for suspected pleural infection, irrespective of community-acquired or hospital-acquired in nature * Pleural tapping will be performed for pleural fluid analysis * Chinese ethnicity * Aged 18 years old or above Exclusion Criteria: * Use of antibiotics for more than 24 hours for the current episode of infection * On long-term local or systemic antibiotics * Tuberculous pleuritis * Pregnant or lactating women * Failed to obtain informed consent due to patient's refusal or cognitive impairment Control group (patients with effusions but not parapneumonic in nature) Inclusion Criteria: * Pleural effusion is not related to any infection including pneumonia (e.g. malignancy, fluid overload) * Pleural tapping will be performed for pleural fluid analysis * Chinese ethnicity * Aged 18 years old or above Exclusion Criteria: * The use of systemic (including oral and intravenous) and inhaled antibiotics in the past 1 month * On long-term local or systemic antibiotics * Tuberculous pleuritis * Pregnant or lactating women * Failed to obtain informed consent due to patient's refusal or cognitive impairment
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What it tests

  • 16S rRNA gene amplicon sequencing
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Where

1 site
Chinese University of Hong Kong
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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