AZA + Venetoclax as Maintenance Therapy in Younger Adults With AML in First Remission

Inclusion Criteria: 1. Diagnosis of favorable-risk acute myeloid leukemia (AML) according to revised 2017 European LeukemiaNet genetic risk stratification and are not immediate candidates for allogeneic stem cell transplant. 2. Aged 18-64 years. 3. Patients who have received remission induction therapy and 3-4 HiDAC or medium-dose cytarabine-based consolidation and are in their first remission. 4. ECOG performance status of \< or = 3. 5. Adequate organ function as follows: 1. Serum total bilirubin \< or = to 3 X the Upper Limit of Normal (ULN) 2. Aspartate Transaminase and alanine transaminase \< or = to 3 x ULN 3. Ccr（Creatinine Clearance Rate) \> or ＝60 ml/min 4. Left ventricular ejection fraction \> or ＝50% determined by ultrasound. 6. For females of childbearing age, they should have a negative serum or urine pregnancy test within 10 to 14 days of enrolling. 7. For males of childbearing age, they should take effective contraceptive methods throughout the treatment period and up to 30 days after discontinuing treatment. 8. Ability to understand and sign informed consent. Exclusion Criteria: 1. Acute promyeloid leukemia. 2. Patients with active central nervous system (CNS) leukemia. 3. Previously diagnosed with myelodysplastic syndrome (MDS) or myeloproliferative neoplasm(MPN) and progressed to AML. 4. Patients with other progressive malignancies. 5. Evidence of other clinically significant uncontrolled condition(s) including, but not limited to uncontrolled and/or active systemic infection (viral, bacterial or fungal). 6. Patients who have participated in other trials within 30 days before signing the informed consent. 7. Females who are pregnant or lactating or intending to become pregnant during the study.