Efficacy and Safety of Long-term Oral Staphylococcus Albicans Tablets in Patients With Bronchiectasis

Inclusion Criteria: * Patients with bronchiectasis diagnosed by clinical manifestations and chest HRCT according to the diagnostic criteria for bronchiectasis; * Patients with idiopathic or post-infectious bronchiectasis; * 18years old; * Patients should have at least 2 acute exacerbations within 1 year before enrollment; * Patients in either acute exacerbation or stable period can be included. Exclusion Criteria: * Cystic fibrosis; * Immunodeficiency, allergic bronchopulmonary aspergillosis, etc.; * Traction bronchiectasis caused by severe emphysema or advanced pulmonary fibrosis; * Still smoking; * Complicated with asthma or chronic obstructive disease Lung; * Patients with severe cardiovascular disease, severe neurological disease, or severe liver or kidney damage; * Malignant tumors; * Allergy to Staphylococcus albicans tablets; * Patients with a history of gastric ulcer or intestinal malabsorption; * Pregnant or lactating women; * patients with poor compliance; * previous (within 6 months before the start of the study) or concurrently taking immunostimulating drugs (including thymosin, interferon, transfer factor, BCG, pneumonia vaccine and any kind of bacteria Extracts, such as Biostim, except for influenza vaccine) or immunosuppressants; * Patients who are participating in or have participated in interventional clinical trials within 3 months.