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Feasibility of End-tidal Oxygen Concentration Monitoring During Preoxygenation for Intubation in the Intensive Care Unit.

RecruitingNAAges 18 Years - anyAllCentre Hospitalier Régional d'Orléans
NCT05409573 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Intubation is a common procedure in the intensive care unit. Hypoxemia is the most frequent complication of this procedure. Monitoring the end-tidal of oxygen is recommended in operating room (OR). End-tidal of oxygen (EtO2) \>90% is an indication of a correct preoxygenation. This monitoring is not used in routine in intensive care unit (ICU). There is no recommendation on the monitoring of end-tidal of oxygen in intensive care unit. In practice, clinicians use pulsed oxygen saturation (SpO2) to determine whether the patient is sufficiently preoxygenated. However, this parameter is not a good indicator of a correct preoxygenation. In the OR, patients are compliant during the preoxygenation period and the measure of EtO2 with the face mask monitor is considered reliable because i) mask leakage is minimal and ii) the patient can breathe slowly and regularly. Theses conditions are not a

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Requiring an intubation in ICU for acute respiratory failure defined as a respiratory rate ≥ 25/min or clinical signs of respiratory distress or hypoxemia defined as oxygen requirement ≥ 15L/min or FiO2 ≥80% to maintain SpO2 ≥92% or a PaO2/FiO2 ratio \<100 mmHg * With preoxygenation by noninvasive ventilation Exclusion Criteria: * Intubation for cardiac arrest * EtO2 monitoring not available * Pulsed oxygen saturation monitoring specific for the study not available * Preoxygenation by high-flow nasal oxygen therapy or bag-mask ventilation * Allergy to lidocaine (for local nasal anesthesia) * Previously * Patient not affiliated or excluded from social protection, or under law protection (namely minors, pregnant or breastfeeding women, persons deprived of their liberty by court or administrative decision) * Previously included in the study
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What it tests

  • double monitoring of EtO2
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Where

1 site
CHR d'ORLEANS
Orléans, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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