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Hybrid Ablation of Atrial Fibrillation in Heart Failure

RecruitingNAAges 18 Years - anyAllSt. George's Hospital, London
NCT05411614 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A randomised controlled trial to assess the efficacy of staged hybrid ablation when compared with standard catheter ablation in patients with non-paroxysmal atrial fibrillation (AF) and Heart Failure

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years * Persistent or Long-standing Persistent AF * Dilated left atrium (at least moderately dilated) * Suitable for either procedure * LVEF \< 50% Exclusion Criteria: * Not yet optimised from a medical or lifestyle perspective for AF or heart failure * Unable to provide written consent * Previous open-heart surgery * Active infection, oesophageal ulcer stricture or oesophageal varices * Prior catheter ablation of atrial fibrillation (prior ablation for atrial flutter / supraventricular tachycardia or ventricular arrhythmia acceptable) * Contraindication to anticoagulation, or active thrombus in the left atrium despite therapeutic anticoagulation * Severe valvular heart disease * Unstable coronary artery disease * Uncontrolled ventricular arrhythmia * Heart attack or stroke within the last 90 days * Pregnant, breastfeeding, or women of childbearing age who plan to get pregnant within six months * Severe concomitant condition or presence of an implanted device that would preclude the patient from undergoing trial procedures
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What it tests

  • AtriCure EPi-Sense-AF Guided Coagulation System +/- Atriclip
  • Endocardial Catheter Ablation
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Where

7 sites
Ashford & St Peters Hospital NHS Trust
Chertsey, United Kingdom
Epsom General Hospital
Epsom, United Kingdom
Cromwell Hospital
London, United Kingdom
Royal Surrey County Hospital
London, United Kingdom
St Anthonys Hospital
London, United Kingdom
St Georges at Kingston Hospital
London, United Kingdom
St Georges University of London
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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