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Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)

RecruitingNAAges 50 Years - 90 YearsMaleUniversity of Nottingham
NCT05414292 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

As people age, muscle mass and function is lost and exercise training is an important way to reduce the effects of this and remain independent. However, not everyone can perform this exercise and the muscle responses to exercise are often reduced in older people. So far there has been no drug found to specifically treat or reduce this problem. Muscle size depends on the balance of muscle protein breakdown and synthesis (building). This balance is regulated by multiple signals within the body, but a particular molecule - the mechanistic target of rapamycin (mTOR), is known to play an important role. For protein synthesis to build up the muscles, this pathway is needed to start the process when triggered by eating protein or exercise. Although this would suggest that mTOR activity is good, excessive levels of this signalling seem to have negative impacts on muscle maintenance with age. I

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study * Participant is physically able to complete the resistance exercise training programme Exclusion Criteria: * • A BMI \<18 or \>35 kg/m2 * Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent stroke * Any metabolic disease * Clotting dysfunction * A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy) * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance (this must remain for ALL UoN FMHS UREC approved studies) * Contraindications to MRI scanning including claustrophobia, pacemaker, metal implants etc. which will be assessed through an MRI safety screening questionnaire. * Contraindications to the use of Rapamycin e.g. those due scheduled vaccinations (as rapamycin can reduce the efficacy of vaccines).
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What it tests

  • Rapamune (sirolimus) 1Mg Tablet
  • Unilateral resistance exercise training
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Where

1 site
University of Nottingham School of Medicine
Derby, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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