🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial

RecruitingPhase 4Ages 18 Years - anyAllWake Forest University Health Sciences
NCT05421741 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

This prospective randomized clinical trial will compare outcomes between patients treated primarily with a prophylactic antibiotic coated nail and those treated with traditional standard of care intramedullary (IM) nailing.

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Patients 18 years or older * Gustilo Type II or III open tibia fracture requiring definitive fixation with intramedullary nail Exclusion Criteria: * Less than 18 years of age * Allergy to vancomycin or gentamicin * Unable to speak English or Spanish * Pregnant and lactating women * Prisoner * Unable to follow up for 12 months
💊

What it tests

  • Antibiotic coated intramedullary Nail
  • Standard Intramedullary Nail
📍

Where

15 sites
University of Florida Gainesville
Gainesville, United States
Florida Orthopaedic Institute
Temple Terrace, United States
Atrium Health Navicent
Macon, United States
The University of Chicago
Chicago, United States
University of Kentucky
Lexington, United States
University of North Carolina Chapel Hill
Chapel Hill, United States
Atrium Health Carolinas Medical Center
Charlotte, United States
Atrium Health Cabarrus
Concord, United States

…and 7 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy