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Renal Nerve Stimulation in Uncontrolled Hypertensive Patients Undergoing Renal Denervation

RecruitingPhase 4Ages 20 Years - anyAllNational Taiwan University Hospital
NCT05421767 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Study design: Investigator initiated, single center The study is aimed 1\) To investigate the blood pressure (BP) change to renal nerve stimulation(RNS), and subsequently perform a renal denervation(RDN) procedure 1\) to verify the cutoff value (RNS-induced systolic BP change \<20 mmHg in post-RDN patients) could be a useful clinical endpoint in RDN therapy, and test the hypothesis that intense RDN could improve the efficacy of RDN.

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📋 Eligibility rules (as published)
Inclusion Criteria: Patients with hypertension (HTN), including 1. 24-hour ambulatory blood pressure \>130/ 80 mmHg 2. Age 20-80 years 3. Glomerular filtration rate \>45 mL/min Exclusion Criteria: 1. Unsuitable renal artery anatomy computed tomographic angiography (main renal artery lumen diameter ≤3 mm or a total length \<20 mm of the main arteries). 2. untreated secondary HTN, including hyperaldosteronism, pheochromocytoma, renal artery stenosis(\>50% stenosis)
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What it tests

  • nerve stimulation guided renal denervation procedure
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Where

1 site
National Taiwan University Hospital
Taipei, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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