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Filter Lifespan in Continuous Renal Replacement Therapy

Recruitingn/aAges 18 Years - anyAllUniversity Hospital Muenster
NCT05450185 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The only supportive therapy for patients with AKI is renal replacement therapy (RRT). In the ICU setting, continuous RRT (CRRT) is mostly favored. In a post-hoc analysis of the RICH trial (regional citrate versus systemic heparin anticoagulation for CRRT in critically ill patient with AKI), it was shown that the filter life span is associated with an increased rate of new infection and that the type of anticoagulants did not directly affect infection rate. The mechanisms of this infection rate is unknown.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients (age ≥18 years) * Critically ill patients with dialysis-dependent AKI * Continuous renal replacement therapy (CRRT) * Written informed consent Exclusion Criteria: * Chronic kidney disease with estimated glomerular filtration rate (eGFR)\<30ml/min/1.73m2 * Chronic dialysis dependency * Kidney transplant * (Glomerulo-)nephritis, interstitial nephritis, vasculitis * Patients on immunosuppression * Patients with chronic inflammatory diseases (e.g. arthritis, HIV, chronic hepatitis) * Persons with any kind of dependency on the investigator or employed by the sponsor or investigator
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What it tests

  • Critically ill patients with continuous renal replacement therapy
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Where

5 sites
Univ.-Klinik Innsbruck
Innsbruck, Austria
Universidade de São Paulo
São Paulo, Brazil
Universitätsklinikum Erlangen-Nürnberg, Abteilung für Nephrologie und Hypertensiologie
Erlangen, Germany
Kliniken Maria Hilf, Klinik für Anästhesiologie und Operative Intensivmedizin
Mönchengladbach, Germany
University Hospital Muenster
Münster, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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