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PET Image in PAH Patients

RecruitingEARLY Phase 1Ages 18 Years - 75 YearsAllStephen Y. Chan
NCT05452889 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pulmonary arterial hypertension (PAH) is mortal disease affecting the blood vessels of the lung. Despite its morbid prognosis, PAH is often misdiagnosed or ignored, with an average time of 44 months between onset of symptoms to diagnosis and substantial progression of disease severity. Therefore, a pressing need exists to develop non-invasive diagnostic imaging tools, particularly that can detect early disease stages. Efforts have been made to develop such imaging capabilities through platform development of echocardiography, cardiac MRI, chest computed tomography (CT), and positron emission tomography (PET), among others. While some have demonstrated promise, few have shown a precise ability to offer disease quantifications of the diseased lung and vasculature itself, to detect early stages of disease, and to reflect alterations of the lung, vasculature, and right ventricle that reflec

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📋 Eligibility rules (as published)
Inclusion Criteria: Cases: 1. Age between 18-75 years old 2. Confirmed diagnosis of SSc-PAH / SSc-eiPAH/IPAH/ by right heart catheterization. And Scleroderma with no PAH confirmand by echo. Controls: 1. Age between 18-75 years old 2. Individuals who are at low risk for current or future cardiovascular or pulmonary symptoms or diseases Exclusion Criteria: Cases: 1. Smoking 2. Pregnant/ breast feeding women 3. Children under 18 4. Inability to read and understand the informed consent 5. History of CT contrast allergy 6. Inability to lie down for long period of time 7. Having claustrophobic 8. History of radiation exposure at workplace 9. Consuming more than 2-3 alcoholic drinks a week 10. Working previously in any of the following "cool miner, painter, iron miner, Mill worker, asbestos, insulation/heat resistance materials, sand" 11. Any medical conditions involving the heart or lungs that would make participation in the study unsafe in the opinion of the PI. Controls: 1. Smoking 2. Pregnant/ breast feeding women 3. Children under 18 4. Inability to read and understand the informed consent 5. History of CT contrast allergy. 6. Inability to lie down for long period of time 7. Having claustrophobic 8. History of radiation exposure at workplace 9. Consuming more than 2-3 alcoholic drinks a week 10. Working previously in any of the following "coal miner, painter, iron miner, Mill worker, asbestos, insulation/heat resistance materials, sand" 11. Any medical conditions involving the heart or lungs or that would make participation in the study unsafe in the opinion of the PI. 12. Family history of Pulmonary Hypertension or Scleroderma
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What it tests

  • 18F-FGLN PET Imaging
  • (18F)FPGLU
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Where

1 site
Montefiore Hospital Clinical and Translational Research Center
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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