🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging

RecruitingNAAges 18 Years - 100 YearsAllUniversity of Florida
NCT05457725 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly underlying the dramatically growing public health problem of elder fraud. Optimal trust-related decision making and avoiding exploitation require the ability to learn about the trustworthiness of social partners across multiple interactions, but the role that learning plays in determining age deficits in trust decisions is currently unknown. Aim: Probe the malleability of the underlying neurocircuitry of trust-learning deficits in aging. This study will utilize real-time fMRI neurofeedback to train older adults in brain activity up-regulation toward enhanced trust-related learning in aging and confirm critical mechanisms of experience-dependent social decisions in a

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Able to provide verbal and written informed consent * Fluent English speaker * At least 8th grade education * On stable medication regimen Exclusion Criteria: * Pregnancy * Magnetic resonance imaging contraindications (e.g., certain metallic objects in body, claustrophobia) * Current major depression defined as scores \>14 on the Beck Depression Inventory-II * Impaired scores on the Telephone Interview for Cognitive Status (TICS; cut-off of \>30) * Current use of medications with significant anticholinergic properties due to potential influence on memory ("memory enhancing"; e.g., Aricept or Namenda) * Current use of anticonvulsant, neuroleptic, sedatives, or other medications known to affect cognition * Uncorrected visual and hearing impairments * Neurologic conditions affecting the brain (e.g., severe stroke, epilepsy, traumatic brain injury with \>30-minute loss of consciousness) * Impaired scores on a cognitive screening measure, the Montreal Cognitive Assessment (MoCA); for older adults the cutoff will be age and education corrected * Unstable medical illness (e.g., metastatic cancer) * Significant cardiovascular conditions (e.g., major heart attack) * Will not exclude participants who are taking anti-depressant medications. Use of antidepressants (particularly SSRI's) and anxiolytic medications will be recorded and included in post-hoc analyses
💊

What it tests

  • Contingent rtfMRI neurofeedback training
  • Non-contingent/sham rtfMRI neurofeedback training
📍

Where

1 site
University of Florida
Gainesville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy