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Can Brief Exposure to Hyperoxia Improve Function After Chronic Spinal Cord Injury?

RecruitingEARLY Phase 1Ages 18 Years - 65 YearsAllUniversity of Alberta
NCT05467215 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This proof-of-principle study will determine if breathing an increased concentration of oxygen above the concentration in normal room air results in changes in the sensory and motor function in people with subacute or chronic, severe spinal cord injury (SCI).

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Individuals with traumatic SCI with onset ≥3 months prior, 2. Between 18 - 65 yr old, 3. ASIA Impairment Scale at discharge classified as A, B or C, 4. Injury level between C5 and T10, 5. Able to give informed, written consent. Exclusion Criteria: 1. Frequent uncontrolled autonomic dysreflexia, 2. Uncontrolled high blood pressure, 3. Cardiac or cardiovascular disease, 4. Cancer, 5. Active urinary tract infection, 6. Active pressure sores, 7. Signs of deep vein thrombosis in the legs, 8. Severe swelling of the feet and/or legs, 9. Severe cognitive impairment, 10. Pulmonary dysfunction such as chronic obstructive pulmonary disease or acute respiratory infection, 11. Any condition which would be exacerbated by sitting or lying in one position for 2 hours, such as low back pain 12. Pregnancy.
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What it tests

  • Pure oxygen (99%) from Praxair, Edmonton, DIN# 02014408
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Where

1 site
University of Alberta, Clinical Sciences Bldg
Edmonton, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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