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3D-MRE for Assessing Cirrhosis, Advanced Chronic Liver Disease and Portal Hypertension

Recruitingn/aAges 18 Years - 75 YearsAllShengjing Hospital
NCT05475015 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

How to construct a novel, non-invasive, accurate, and convenient method to achieve prediction of hepatic venous pressure gradient (HVPG) is an important general problem in the management of portal hypertension in cirrhosis or advanced chronic liver disease. We plan to investigate the ability of three demensional-magnetic resonance elastography (3D-MRE) to establish a risk stratification system and perform tailored management for portal hypertension in cirrhosis or advanced chronic liver disease.

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion criteria were: (1) โ‰ฅ18 years; (2) written informed consent; (3) confirmed ACLD of any liver disease etiology; (4) clinically indicated for HVPG measurement, with 3D-MRE performed within one month prior. Exclusion criteria were: (1) hepatic or extrahepatic malignancies, or large hepatic or splenic focal diseases affecting MRE measurement; (2) MR or HVPG contraindications; (3) prior liver or splenic surgery affecting MRE measurement; (4) treatment with nonselective ฮฒ-blockers (NSBB) between MRE and HVPG measurements; (5) invalid or unreliable HVPG or MRE results and (6) biliary obstruction or dilation on MR images.
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What it tests

  • 3D-MRE
  • HVPG
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Where

1 site
Shengjing Hospital
Shenyang, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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