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Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments

RecruitingNAAges 18 Years - 90 YearsAllCarle Foundation Hospital
NCT05479006 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Significant motor impairments occur in 80% of individuals after moderate to severe stroke and impact the body side to the lesioned hemisphere. Typical motor impairments involve loss of dexterity with highly prevalent upper limb flexion synergy. Advances in treating flexion synergy impairments have been hampered by a lack of precision rehabilitation. Previous studies suggest and support the role of cortico-reticulospinal tract (CRST) hyperexcitability in post-stroke flexion synergy. CRST hyperexcitability is often caused by damage to the corticospinal tract (CST). We hypothesize that: 1) inhibiting the contralesional dorsal premotor cortex (cPMd) will directly reduce the CRST hyperexcitability and thus, reduce the expression of the flexion synergy; 2) facilitating the ipsilesional primary motor cortex (iM1) will improve the excitability of the damaged CST, therefore reducing the CRST hype

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📋 Eligibility rules (as published)
Inclusion Criteria: * Paresis confined to one side, with substantial motor impairment of the paretic upper limb * Capacity to provide informed consent Exclusion Criteria: * Muscle tone abnormalities and motor or sensory impairment in the non-paretic limb * Severe wasting or contracture or significant sensory deficits in the paretic upper limb * Severe cognitive or affective dysfunction that prevents normal communication and understanding of consent or instruction * Severe concurrent medical problems (e.g. cardiorespiratory impairment) * Using a pacemaker * Metal implants in the head * Known adverse reactions to TMS and tDCS * Pregnant
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What it tests

  • Transcranial direct current stimulation (high- definition)
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Where

1 site
Carle Foundation Hospital
Urbana, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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