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Predictive Factors for Treatment Response in Patients With Newly-diagnosed Polymyalgia Rheumatica and Giant Cell Arteritis

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT05479448 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This prospective study is to explore different predictive factors for response to steroid treatment in patients with PMR and/or GCA. It evaluates the association of endogenous GC suppression (plasma and urinary cortisol and cortisone) to the responsiveness of PMR/GCA to GCs.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with diagnosis of PMR according to the 2012 provisional classification criteria and GCA according to published criteria * Consent to participate in the SCQM database * Treatment according to our standardized regimes Exclusion Criteria: * Treatment with Tocilizumab, MTX or other disease modifying medications at inclusion * History of GCA and PMR in the past * Inability to give informed consent
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What it tests

  • Data collection for cellular analyses (Immune subset composition, GCR expression, in vitro steroid responsiveness)
  • Data collection for exploratory analyses of endogenous steroid hormones
  • Data collection for correlation between clinical defined and lab defined GC responsivness
  • Data collection for Prednisone metabolism
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Where

1 site
Department of Rheumatology University Hospital Basel
Basel, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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