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Soluble Fibre Supplementation in NAFLD

RecruitingPhase 2Ages 8 Years - 17 YearsAllMcMaster University
NCT05480696 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The FIND study will look at the effect of a nutritional mixed fibre supplement, oligofructose and inulin (OF+INU), on children with non-alcoholic fatty liver disease. In this randomized, double- blind controlled trial, subjects will be given a supplement, in the form of oral pills, and will have bloodwork performed, their diets analyzed, and liver fat measured at several timepoints. Liver fat will be measured by using a specialized MRI device located at St. Joseph's Hospital. Subjects will be recruited from the Children's Exercise and Nutrition Clinic.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Children ages 8-17 years * Diagnosed with obesity (BMI ≥2 standard deviations above WHO reference median) * Enrolled in GHWM Clinic * Clinical evidence of NAFLD (elevation of ALT, greater than 2x upper-limit-of-normal (ULN) \[ALT\>80 IU/L for 8-17 years of age\], and hepatic steatosis measured as part of clinic enrolment). Exclusion Criteria: * Type 1, Type 2 diabetes mellitus (T1DM, T2DM) * Contraindications to having MRI (claustrophobia, metal implant, recent tattoo, weight \> 300lbs) * Concomitant use of other fibre supplements * Medications known to affect hepatic fat content, taken within the past year (i.e., glucocorticoids, anabolic steroids, tetracycline, anticonvulsants, antipsychotics, glucose- lowering medications) * Presence of another known cause of liver disease * Known allergy or hypersensitivity to OF-INU supplementation * Self-reported alcohol intake \>7 drinks/week or 3 drinks/day
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What it tests

  • Fructo-oligosaccharide enriched inulin supplement
  • Maltodextrin
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Where

1 site
McMaster University Medical Center
Hamilton, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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