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MultiSENSory Stimulation to TArgeT Sensory Loss and ChronIc Pain in NeurOpathic PatieNts

RecruitingNAAges 18 Years - 80 YearsAllETH Zurich
NCT05483816 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Neuropathy is a costly and disabling health issue, which consists of a degeneration of the peripheral nerves. Even though the causes may be different, such as diabetes or amputation, the consequences for neuropathic patients are multiple and extremely debilitating. Among the alarming symptoms it implicates, chronic pain and sensory loss are among the most severe ones. Because of the loss of sensations, patients are forced to have an altered gait strategy, an impaired balance and a fivefold increased risk of falling. Furthermore, since they lose sensations and feel numbness in their extremity, they are discouraged in walking, hence leading to a sedentary lifestyle. All of this is worsened by the development of neuropathic pain, which has a high comorbidity with psychological issues, such as depression and anxiety. Today, proper treatments for neuropathic pain that exclude pharmacological

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📋 Eligibility rules (as published)
for healthy: * Inclusion: * Age 18-80 * Visual acuity\>6 on Snellen visual acuity chart * Exclusion: * Pregnancy * Cognitive deficits (Mini Mental State Examination\<23) * Cyber-sickness * Prior or current psychological diseases * Pacemakers * Epilepsy * Claustrophobia * Other MRI contraindications * Unhealed fractures * Unhealed wounds * Cancerous growth in proximity to feet * Swollen, infected or inflamed areas on feet or skin eruptions on feet such as phlebitis, thrombophlebitis or varicose veins for patients: * Inclusion: * Age 18-80 * Visual acuity\>6 on Snellen visual acuity chart * Diagnosis of peripheral neuropathy * Pain in lower limbs\>=3 cm on VAS scale * Exclusion: * Pregnancy * Relevant comorbidities that would affect the outcomes of the study (by judgement of physicians) * Ulcers * Cognitive deficits (Mini Mental State Examination\<23) * Cyber-sickness * Prior or current psychological diseases * Pacemakers * Epilepsy * Claustrophobia * Other MRI contraindications * Unhealed fractures * Unhealed wounds * Cancerous growth in proximity to feet
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What it tests

  • VR+TENS
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Where

1 site
ETH Zurich
Zurich, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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