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Lactobacillus Reuteri Strain Combination in Children Treated With PPI

RecruitingNAAges 12 Months - 14 YearsAllUniversity of Bari
NCT05484128 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Probiotics might be of help in preventing dysbiosis and emergence of SIBO. Gastrus consisted of a mixture of two human strains of L. Reuteri DSM 17938 and ATCC PTA 6475; the first have extensive data supporting its use in gastric infections (18) however, it lacks the anti-inflammatory properties that have been provided by L. Reuteri DSM ATCC PTA 6475 that has excellent acid resistance and has strong anti-inflammatory properties (19); for these reasons, Gastrus is the best candidate for this indication.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age: children between 1 month and 14 years of age; o We start with children older than 4 years of age. * Necessity of therapy with Proton Pump Inhibitors for Gastroesophageal reflux disease and/or Functional Dyspepsia; * Informed consent obtained. Exclusion Criteria: * Neurological pathologies (PCI and Spastic tetra-paresis); * Nasogastric feeding; * Known immunodeficiency; * Previous therapy with gastric acid inhibitors; * HP infection; * Assumption of prebiotics, other probiotics or symbiotics in the previous month; * Malnutrition or severe dystrophy; * Cystic Fibrosis.
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What it tests

  • Gastrus
  • Placebo
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Where

1 site
Fernanda
Bari, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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