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โ† Trials
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Letrozole in Preventing Recurrence of Endometrioma Following Laparoscopic Ovarian Cystectomy

RecruitingNAAges 18 Years - 45 YearsFemaleThe University of Hong Kong
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In plain words

What the trial is, and whether it could suit you

Endometriosis is a chronic inflammatory disease that affects approximately 10-15% of women of reproductive age. Symptoms include dysmenorrhoea, chronic pelvic pain, dyspareunia and infertility. Removal of the endometriotic cyst (chocolate cyst) by surgery is a well-established treatment for symptomatic relief. However, recurrence of endometriotic cyst after surgical removal of the cyst is up to 30-50% after ovarian surgery. Oral contraceptive pills for 18-24 months after the surgery is widely used as a postoperative hormonal therapy because it has been shown to reduce the chance of recurrence of the endometriotic cyst, but recurrence is still high even after taking oral contraceptive pills. Letrozole is an aromatase inhibitor. There are some preliminary reports that letrozole can cause shrinkage of endometriotic cysts and improve endometriosis-related pelvic pain by reducing oestrogen l

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Women aged 18-45 years old * Scheduled to have laparoscopic ovarian cystectomy * Unilateral or bilateral endometrioma on pre-operative ultrasound and confirmed by histology Exclusion Criteria: * Use of long-acting hormonal therapy in the 3 months before inclusion in the study * Histological report of laparoscopic ovarian cystectomy showed atypical endometrioma * Complex surgery including resection of deep infiltrating disease, bowel resection or hysterectomy * Incomplete excision of endometrioma/ incision or drainage rather than ovarian cystectomy * Suspicion of malignancy * Contraindications to combined oral contraceptive pills, including: uncontrolled hypertension (systolic \> 160mmHg or diastolic \> 100mmHg), diabetes with retinopathy/ nephropathy/ neuropathy, current or past history of venous thromboembolism, ischemic heart disease, history of cerebrovascular accident, migraine with aura, severe liver disease, oestrogen-sensitive cancers, undiagnosed abnormal uterine bleeding, smokers (\> 15 cigarettes/day) aged 35 years or above, or having body mass index \>=35 kg/m2 * Planning to get pregnant in the coming 1 year * Refusal to join the study
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What it tests

  • Letrozole
  • Placebo
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Where

5 sites
Queen Mary Hospital
Hong Kong, Hong Kong
Kwong Wah Hospital
Hong Kong, Hong Kong
Pamela Youde Nethersole Eastern Hospital
Hong Kong, Hong Kong
Princess Margaret Hospital
Hong Kong, Hong Kong
Queen Elizabeth Hospital
Hong Kong, Hong Kong
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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