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MiECC Versus Conventional Cardiopulmonary Bypass in Cardiac Surgery (MiECS)

RecruitingNAAges 18 Years - 85 YearsAllAristotle University Of Thessaloniki
NCT05487612 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

MiECS is one of the largest multicentre randomised controlled trials on extracorporeal circulation conducted under the auspices of Minimal Invasive Extracorporeal Technologies International Society (MiECTiS). It is designed to ultimately address the emerging effectiveness of MiECC systems in the light of modern perfusion practice worldwide. The primary hypothesis is that MiECC, as compared to conventional CPB (cCPB), reduces the proportion of patients experiencing serious perfusion-related postoperative morbidity after cardiac surgery. The study will be led by the Clinical Research Unit of the Special Unit for Biomedical Research and Education (SUBRE), Aristotle University of Thessaloniki School of Medicine in Greece (AUSoM) with Chief Investigator Professor Kyriakos Anastasiadis, who is a key-opinion-leader in the field of MiECC, founder and Executive Board of MiECTiS.

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📋 Eligibility rules (as published)
Inclusion Criteria: * All patients undergoing any elective or urgent coronary artery bypass grafting (CABG), aortic valve replacement (AVR) or CABG+AVR surgery using extracorporeal circulation without circulatory arrest. Exclusion Criteria: * Requirement for emergency or salvage operation. * Requirement for major aortic surgery (e.g. aortic root replacement). * Contraindication or objection (e.g. Jehovah's Witnesses) to transfusion of blood products. * Congenital or acquired platelet, red cell or clotting disorders (patients with iron deficient anaemia will not be excluded). * Inability to give informed consent for the study (e.g. learning or language difficulties).
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What it tests

  • Minimal Invasive Extracorporeal Circulation
  • Conventional cardiopulmonary bypass
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Where

13 sites
Perfusion Services University Health Network, Toronto General Hospital
Toronto, Canada
Department of Cardiac Surgery
Coswig, Germany
Department of Thoracic and Cardiovascular Surgery, University Medical Centre Goettingen
Göttingen, Germany
Department of Cardiothoracic and Vascular Surgery, Ulm University Hospital
Ulm, Germany
Cardiothoracic Department AHEPA University Hospital
Thessaloniki, Greece
Department of Cardiac Surgery GVM Anthea Hospital
Bari, Italy
Department of Cardiac Surgery GVM Maria Eleonora Hospital
Palermo, Italy
Department of Cardiovascular Surgery, Ankara City Hospital
Ankara, Turkey (Türkiye)

…and 5 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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