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A Study of Reduced Dosing of the Nonavalent HPV Vaccine in Women Living With HIV

RecruitingPhase 4Ages 18 Years - 45 YearsFemaleUniversity of British Columbia
NCT05495906 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

There are very little data on human papillomavirus (HPV) vaccination among the 18 million women living with HIV (WLWH) globally, who constitute a population most vulnerable to HPV and the resultant cervical cancer. Particularly, there are no data to date on reduced-dose schedules of nonavalent HPV (9vHPV) vaccination in WLWH and there are very little data on the 9vHPV vaccine in this population overall. It is critical to examine the 9vHPV vaccine in WLWH now because the quadrivalent HPV (4vHPV) vaccine has been discontinued. Additionally, in order to reach the World Health Organization's global goal of cervical cancer elimination, we must determine the role of various HPV prevention strategies in this important population including reduced vaccine dosing which can drastically increase the feasibility of HPV vaccination programs globally. This randomized clinical trial will enrol WLWH ag

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📋 Eligibility rules (as published)
Inclusion Criteria: * Living with HIV * Has a uterine cervix Exclusion Criteria: * Unable to give fully informed consent * Pregnant or unwilling to avoid pregnancy during vaccination * Allergy to the vaccine or its components * Prior receipt of any HPV vaccine
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What it tests

  • Nonavalent HPV vaccine
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Where

10 sites
Positive Health Services - Fraser Health
Surrey, Canada
University of British Columbia
Vancouver, Canada
Health Sciences Centre
Winnipeg, Canada
Hamilton Health Sciences
Hamilton, Canada
St. Michael's Hospital
Toronto, Canada
Toronto General Hospital
Toronto, Canada
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Canada
McGill University Health Centre
Montreal, Canada

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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