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PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis

Recruitingn/aAges 18 Years - anyFemaleMaastricht University Medical Center
NCT05500989 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Pregnancy is considered a cardiovascular (CV) stress test, and complicated pregnancies are associated with an increased risk for cardiovascular disease (CVD) later in life. Moreover, it is known that often the pregnancy induced CV adaptation does not resolve completely after a short postpartum (PP) period and it is not clear whether these induced changes will resolve over a longer period of time (i.e. in the upcoming months/years after delivery). Understanding the cardiac adaptation during pregnancy and the reversal process in the postpartum period, as well as the factors that influence this these processes, may provide us not only insight in this mechanism, but may help us in identifying factors that may be target points for modification.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women aged ≥ 18 years * Controls: Women with an uncomplicated pregnancy at the moment of inclusion (i.e no foetal or maternal placental complications, such as pregnancy induced hypertension, preeclampsia or HELLP-syndrome, or small for gestational birth infancies) * Cases: Women diagnosed with a preeclamptic pregnancy at the moment of inclusion Exclusion Criteria: • Women who do not want to be informed about the results of the tests, or women who do not want their general practitioner and specialist(s) to be informed about the test results * Allergy or intolerance to glyceryl trinitrate, betablockers or iodinated contrast media. * Controls: Pre-existing chronic hypertension treated with antihypertensive medication or autoimmune disorder.
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What it tests

  • Not listed
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Where

1 site
Maastricht University Medical Center (MUMC+)
Maastricht, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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