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The Effect of SAAE on Ventricular Remodeling in PA Patients

RecruitingNAAges 18 Years - 60 YearsAllSecond Affiliated Hospital of Nanchang University
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In plain words

What the trial is, and whether it could suit you

The study aims to assess the effect of superselective adrenal arterial embolization on ventricular remodeling in primary aldosteronism without lateralized aldosterone secretion by comparing it with spironolactone therapy.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * (1) Age 18-60 years old, regardless of gender; * (2) Blood pressure conditions meet one of the following: 1) Office blood pressure โ‰ฅ 140/90mmHg; 2) Ambulatory blood pressure monitoring whole day blood pressure \> 130/80 mmHg or daytime blood pressure \> 135/85 mmHg; * (3) After strict drug elution, it met the diagnostic criteria of primary aldosteronism, and bilateral primary aldosteronism was confirmed by adrenal venous sampling; * (4) No surgical intent or contraindication to surgery and willing to undergo pharmacological treatment or percutaneous superselective adrenal artery embolization; * (5) The patient or his/her legal representative shall sign the written informed consent approved by the ethics committee before the screening. Exclusion Criteria: * (1) Primary hypertension or secondary hypertension with other causes; * (2) A woman who is pregnant or lactating, or has a birth plan for the next year; * (3) There are serious organic diseases, especially liver and kidney dysfunction(eGFR\<45 mL/min/1.73 m2); * (4) Severe allergy to contrast medium; * (5) Other serious organic diseases, life expectancy \< 12 months; * (6) Adrenal CT showed adenoma.; * (7) Patients are enrolled or want to participate in other clinical studies. During the enrollment study, the results of this study will be affected.
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What it tests

  • Super selective adrenal artery embolization
  • Spironolactone
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Where

1 site
The Second Affiliated Hospital of Nanchang University
Nanchang, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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