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How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.

Recruitingn/aAges 2 Years - 18 YearsAllEva Ponten
NCT05506228 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

* Cerebral palsy (CP) is a motor disorder caused by an injury to the immature brain. Even though the brain damage does not change, children with CP will have progressively weaker, shorter and stiffer muscles that will lead to contractures, bony deformations, difficulty to walk and impaired manual ability. An acquired brain injury (ABI) later during childhood, such as after a stroke or an injury, will result in similar muscle changes, and will therefore also be included in this study. For simplicity, these participants will in this text be referred to as having CP. * The mechanism for the muscle changes is still unknown. Contractures and the risk for the hips to even dislocate is now treated by tendon lengthening, muscle release and bony surgery. During these surgeries muscle biopsies, tendon biopsies and blood samples will be taken and compared with samples from typically developed (TD)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Children and adolescents undergoing clinically needed orthopaedic surgery * with Cerebral Palsy or Acquired Brain Injury * Typically developed children and adolescents (control) Exclusion Criteria: * for CP/ABI: Progressive neurological disease, other metabolic or muscle disease * for TD (Control): Cerebral Palsy, Acquired Brain injury, other metabolic or muscle diseases
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What it tests

  • No intervention
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Where

1 site
Karolinska University Hospital
Stockholm, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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